The Villa Lab develops tools to observe macromolecular complexes in their natural environment, the cell. Our ultimate goal is to unveil the structural dynamics of these complexes while they go about their everyday life. We combine cell biology and electron microscopy to generate data, and we use image processing and physical modeling to understand these data.
Digvijay’s work on the in situ yeast NPC has been posted on bioRxiv. This work was a massive collaboration with the labs of Chris Akey, Mike Rout, Andrej Sali, and Steve Ludke.
Elizabeth is selected as a Howard Hughes Medical Institute (HHMI) Investigator. This wonderful opportunity which was only possible through the work of lab members through the years, will allow us to continue to pursue high-risk research. We’re so excited!
Elizabeth is promoted to associate professor with tenure. This was possible thanks to the amazing past and present lab members, our fantastic collaborators, and the very supportive environment at UC San Diego Biological Sciences that allowed us to build a complex research infrastructure from scratch. Let’s go!
Matt’s paper describing the use of entropy regularized deconvolution for cryo-ET is now on bioRxiv. This was the produce of a longstanding collaboration with John Sedat.