13 Jan

Bacterial Nucleus

In collaboration with the Poglianos and Agard labs, we unveiled how very large viruses affect the cellular machinery of bacteria during infection. The most exciting finding: segregation of the (viral) genetic material inside a shell forming a nucleus-like compartment that  separates transcription and translation!  We used cryo-FIB milling and cryo-electron tomography to reveal the molecular details of this phenomenon.  Read our paper and watch a movie.

31 Oct


My dearest advisor, mentor, and friend Klaus Schulten passed away today.  Words cannot express the sadness.  We will miss his pioneering spirit, brilliance, creativity, humor, and warmth. His legacy will continue to advance and inspire our scientific lives!

The Villa Lab