Macromolecules rarely operate in isolation inside cells. At any given time, the average protein is part of a complex of over 10 macromolecules, and these supramolecular complexes are in turn embedded in intricate networks inside cells. We are broadly interested in revealing the structure and function of macromolecular complexes in their natural environment at the highest possible resolution in order to reveal their structural dynamics and interactions. We call it bringing structure to cellular biology.
Our thrust in this area includes projects such as: the structural dynamics of the yeast nuclear pore complex, the mechanical communication between the cytoskeleton and the nucleus, and the molecular architecture of the genome and its association to the nuclear envelope.