Elizabeth is promoted to associate professor with tenure. This was possible thanks to the amazing past and present lab members, our fantastic collaborators, and the very supportive environment at UC San Diego Biological Sciences that allowed us to build a complex research infrastructure from scratch. Let’s go!
Matt’s paper describing the use of entropy regularized deconvolution for cryo-ET is now on bioRxiv. This was the produce of a longstanding collaboration with John Sedat.
Josh’s PhD paper is now published in Nature Communications.
Our paper in collaboration with the Shapiro lab was posted to bioRxiv. This work deciphers the molecular grammar of the bacterial protein PopZ in forming phase-separated compartments, and uses PopZ as a synthetic tool in human cells. Vinson used cryo-ET to show that altering protein domain composition changes structural order of the compartments and affects ribosome distribution in cells.
Vinson’s chapter titled “Practical Approaches for Cryo-FIB Milling and Applications for Cellular Cryo-Electron Tomography” is published as part of the cryoEM. Methods in Molecular Biology book edited by Tamir Gonen and Brent Nannenga. It has a lot of useful tips and we hope it will help #democratizecryoET.
Our collaboration with the lab of Don Cleveland describing how TDP-43 and HSP70 phase separate into anisotropic, intranuclear liquid spherical annuli is now published after peer review in Science (see preprint here). We’re happy to have contributed to this exciting work. Congratulations Digvijay on capturing these phase separated compartments in the nucleus using cryo-ET!
Elizabeth gives her tenure talk. It has been a challenging year, but we are grateful for the opportunity to do great science in a wonderful environment.