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The Villa Lab develops tools to observe macromolecular complexes in their natural environment, the cell. Our ultimate goal is to unveil the structural dynamics of these complexes while they go about their everyday life. We combine cell biology and electron microscopy to generate data, and we use image processing and physical modeling to understand these data.

03 Feb

NanoPop

Our paper in collaboration with the Shapiro lab was posted to bioRxiv. This work deciphers the molecular grammar of the bacterial protein PopZ in forming phase-separated compartments,  and uses PopZ as a synthetic tool in human cells. Vinson used cryo-ET to show that altering protein domain composition changes structural order of the compartments and affects ribosome distribution in cells.

 

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