13 Jan

Bacterial Nucleus

In collaboration with the Poglianos and Agard labs, we unveiled how very large viruses affect the cellular machinery of bacteria during infection. The most exciting finding: segregation of the (viral) genetic material inside a shell forming a nucleus-like compartment that  separates transcription and translation!  We used cryo-FIB milling and cryo-electron tomography to reveal the molecular details of this phenomenon.  Read our paper and watch a movie.